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Mice can damage stored comb and comb in the hive. They will typically move into both in the late fall as temperatures begin to drop. They seek an area in which to build winter nests and the bee's honey storage provides a nice food source as well. They chew up the comb (and foundation) and they also bring in nesting materials. Overall the effect is one of destruction (remember that mice urinate and defecate everywhere they go) and the bees will attempt to kill the invader. If they succeed, they have no method to remove the mouse, but instead, coat it in propolis to prevent the spread of disease from the decomposing corpse.

If found in supers (occupied or not) capture/kill them immediately. Clean the hive and replace any damaged frames.

Raise your hives off of the ground. Place a mouse guard on the entrance of the colony to prevent them from coming in; use at least an entrance reducer and watch for signs of chewing as mice will chew the wood to make the entrance large enough to get in.